产品目录

CAS号	69558-55-0
分子式	C30H49N9O9
分子量	679.77
结构式
外观	白色或类白色粉末
溶解性	DMSO:100mg/mL(147.1mM)；Water:100mg/mL(147.1mM)；不溶于乙醇
含量	＞98%
储存条件	-20℃，避光防潮密闭干燥。

产品描述	Thymopentin has immuno-regulatory activities.The immuno-regulatory actions of thymopentin on peripheral T cells are mediated by intracellular cyclic GMP elevations in contrast to the intracellular cyclic AMP elevations induced in precursor T cells that trigger their further differentiation to T cells.
体外研究	TP5 displays concentration-dependent inhibitory effects on the proliferation and colony formation of HL-60 cells.the decrease or even disappearance of AgNORs from nucleoli is observed in HL-60 cells after the treatment with TP5.The suppression induced by TP5 is accompanied by an accumulation of cell cycle in the G0/G1 phase.Moreover,TP5 significantly increases the NBT-reduction activity of HL-60 cells.TP5 has induced differentiation along the granulocytes lineage in HL-60 cells.TP5 increases the expression of CD4 and CD8 markers on the surface of human thymocytes.
体内研究	TP5 is able to markedly stimulate the activity of immune system cells in healthy animals.It activates the production of a number of cytokines (IL1α,IL2,IL6,IL10,IFNγ),NO,Hsp70 and Hsp90 in mature cells of the peripheral immune system of mice (peritoneal macrophages and spleen lymphocytes).

科研试剂，广泛应用于分子生物学，药理学等科研方面，严禁用于人体。本品为免疫双向调节药。具有诱导和促进T淋巴细胞及其亚群分化、成熟和活化的功能，调节T淋巴细胞的比例，使CD4+/CD8+趋于正常；调节和增强人体细胞免疫功能的作用，能促使有丝分裂原激活后的外周血中的T淋巴细胞成熟，增加T细胞在各种抗原戒致有丝分裂原激活后各种淋巴因子(如：a、γ干扰素、白介素2和白介素3)的分泌，增加T细胞上淋巴因子受体的水平。它同时通过对T辅劣细胞的激活作用来增强淋巴细胞反应。此外，本品可能影响NK前体细胞的趋化，该前体细胞在暴露于干扰素后变得更有细胞毒性。

	1mg	5mg	10mg
1mM	1.4711mL	7.3554mL	14.7109mL
5mM	0.2942mL	1.4711mL	2.9422mL
10mM	0.1471mL	0.7355mL	1.4711mL
50mM	0.0294mL	0.1471mL	0.2942mL

细胞实验：

Cell lines:HL-60 cells Concentrations:100–800 μmol/L Incubation Time:120h Method:HL-60 cells are plated at a density of 1×105 cells/mL,and cultured for 120h in a medium containing TP5 at various concentrations (100-800 μmol/L).To quantify the number of cells after treatment,cells are counted at different time points of incubation using a hemocytometer under a light microscope.Cell viability is determined by the Trypan blue exclusion assay.Viability is calculated as the ratio of living cells to the total cell population. (Only for Reference)

动物实验：

Animal Models:NMRI mice Formulation:Saline Dosages:15μg/100g Administration:i.p. (Only for Reference)

相关搜索：胸腺五肽，Arg-Lys-Asp-Val-Tyr，Thymopentin Acetate，69558-55-0